摘要
目的 分析阿奇霉素联合甲泼尼龙治疗儿童重症支原体肺炎的应用。方法 选择我院2021年1月-2022年1月儿童重症支原体肺炎患者共70例，数字表随机分2组每组35例，对照组的患者给予阿奇霉素治疗，观察组在该基础上增加甲泼尼龙。比较两组咳嗽等临床表现好转时间、治疗前后患者炎症因子、总有效率、不良反应。结果 观察组体温恢复至正常、咳嗽症状消失、肺啰音消失、住院时间分别为（6.33±2.36）d、（10.05±2.12）d、（7.01±1.91）d、（11.12±2.07）d，均短于对照组的（7.71±2.81）d、（12.13±3.34）d、（12.45±2.33）d、（14.71±2.21）d，P＜0.05。治疗前二组患者炎症因子比较，P＞0.05，而治疗后两组炎症因子均改善，而观察组炎症因子显著低于对照组，P＜0.05。观察组总有效率高于对照组，P＜0.05。两组均无产生严重不良反应，P＞0.05。结论 阿奇霉素联合甲泼尼龙对于儿童重症支原体肺炎的治疗效果确切且安全性高。
关键词： 阿奇霉素；甲泼尼龙；儿童重症支原体肺炎；应用
Abstract
Objective To analyze the application of azithromycin combined with methylprednisolone in the treatment of severe mycoplasma pneumonia in children. Methods A total of 70 children with severe mycoplasma pneumonia in our hospital from January 2021 to January 2022 were selected. The digital table was randomly divided into 2 groups with 35 cases in each group. The patients in the control group were treated with azithromycin. nylon. The improvement time of cough and other clinical manifestations, inflammatory factors, total effective rate, and adverse reactions were compared between the two groups before and after treatment. Results The body temperature of the observation group returned to normal, the cough symptoms disappeared, the lung rales disappeared, and the hospitalization time was (6.33±2.36) d, (10.05±2.12) d, (7.01±1.91) d, and (11.12±2.07) d, respectively. Shorter than the control group (7.71±2.81) d, (12.13±3.34) d, (12.45±2.33) d, (14.71±2.21) d, P<0.05. The comparison of inflammatory factors in the two groups before treatment, P>0.05, and after treatment, the inflammatory factors in both groups were improved, and the inflammatory factors in the observation group were significantly lower than those in the control group, P<0.05. The total effective rate of the observation group was higher than that of the control group, P<0.05. There were no serious adverse reactions in both groups, P>0.05. Conclusion Azithromycin combined with methylprednisolone is effective and safe in the treatment of severe mycoplasma pneumonia in children.
Key words： Azithromycin; Methylprednisolone; Severe mycoplasma pneumonia in children; Application
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