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Open Access Article

International Journal of Internal Medicine. 2021; 2: (1) ; 30-32 ; DOI: 10.12208/j. ijim.20210009.

Cox-2, bFGF expression and angiogenesis in gastric carcinoma tissue significance of clinical studies
COX-2、bFGF在胃癌组织中表达及血管生成意义的临床研究

作者: 井夫春, 潘卫红, 张宇, 宋时荣*,

山东省泰安市中心医院 山东泰安

山东省泰安市中心医院 山东泰安

岚山区妇幼保健计划生育服务中心 山东日照

*通讯作者: 宋时荣,单位:山东省泰安市中心医院 山东泰安;

发布时间: 2021-03-16 总浏览量: 30

摘要

目的 COX-2、bFGF在胃癌组织中表达及血管生成意义开展深入分析。方法 研究人员结合纳排标准,选择了泰安市中心医院2016年1月到2016年6月手术切除并经病理证实、资料完整的胃癌组织标本及其癌旁组织标本各50例,开展免疫组化及RT-PCR分析。结果 胃癌组织的COX-2、bFGF的阳性表达明显高于癌旁5cm组织标本的阳性表达,组间差异具有统计学意义(P<0.05)。CD34在镜下观察主要为分布在血管内皮细胞胞浆,为棕黄色颗粒分布。胃癌组织的CD34分布明显高于癌旁5cm组织标本的阳性表达,组间差异具有统计学意义(P<0.05)。结论 COX-2在胃癌组织中表达明显处于高表达状态,bFGF在胃癌组织中表达处于高表达状态,高于在癌旁5cm组织标本的表达状态。通过 CD34在胃癌组织及癌旁组织中的表达与MVD计数分析,进一步证明COX-2、bFGF、MVD在血管生成过程中存在相关性,协同表达临床意义。

关键词: COX-2;bFGF;胃癌;血管生成

Abstract

Objective in view of the current cox-2, bFGF expression and angiogenesis in gastric cancer tissue significance to carry out in-depth analysis.
Methods researchers combined discharge standard, chose Tai’an City central hospital in January 2016 to June 2016 surgical resection and confirmed by pathology, data integrity of gastric cancer tissue and its tissue adjacent to carcinoma specimens were 50 cases each, immunohistochemistry and rt-pcr analysis.
Results the gastric cancer tissue of positive expression of cox-2, bFGF was obviously higher than that of positive expression of 5 cm tissue adjacent to carcinoma specimens between group differences statistically significant (P<0.05).CD34 in the microscopic observation are mainly distributed in vascular endothelial cell cytoplasm, for tan particle distribution. CD34 distribution of gastric cancer tissue was obviously higher than that of positive expression of 5 cm tissue adjacent to carcinoma specimens between group differences statistically significant (P < 0.05).
Conclusion   the expression of cox-2 in gastric cancer tissues are clearly in a high state, bFGF expression in gastric cancer tissues in a state of high expression, higher than in the expression of 5 cm tissue adjacent to carcinoma specimens. Not only that, by CD34 expression in gastric cancer tissue and tissue adjacent to carcinoma and MVD count analysis, further evidence that cox-2, bFGF and MVD in the process of angiogenesis correlation, coordinated expression of clinical significance.

Key words: Cox-2; BFGF; Stomach cancer; Angiogenesis

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引用本文

井夫春, 潘卫红, 张宇, 宋时荣, COX-2、bFGF在胃癌组织中表达及血管生成意义的临床研究[J]. 国际内科前沿杂志, 2021; 2: (1) : 30-32.