Short term follow-up study of DN regimen combined with 3D-CRT in patientswith advanced esophageal cancer
DN方案联合3D-CRT治疗中晚期食管癌患者的短期随访研究

摘要

目的 研究DN方案联合三维适型放疗（3D-CRT）对中晚期食管癌（EC）患者肿瘤标志物等的影响。方法 选取我院62例中晚期EC患者根据治疗方案不同分为对照组（31例）和观察组（31例）。对照组采用3D-CRT治疗，观察组采用DN方案联合3D-CRT治疗。比较2组临床疗效、吞咽功能分级法评分（Stooler评分）、欧洲癌症研究与治疗组织生命质量量表评分（EORTCQLQ-C30评分）、食管癌患者补充量表评分（QLQ-OESl8评分）、毒副反应。结果 观察组总有效率70.97%高于对照组41.94%（P＜0.05）；治疗后，观察组Stooler评分、QLQ-OESl8评分均低于对照组，EORTCQLQ-C30评分高于对照组（P＜0.05）；2组毒副反应发生率对比无显著差异（P＞0.05）。结论 DN方案联合3D-CRT治疗中晚期EC患者疗效确切，可有效降低机体肿瘤标志物水平，改善患者吞咽功能、生命质量，进一步缓解其临床症状。

Abstract

Objective To study the effect of DN regimen combined with three-dimensional conformal radiotherapy (3D-CRT) on tumor markers in patients with advanced esophageal cancer (EC).
Methods 62 patients with intermediate and late EC in our hospital (October 2019~January 2021) were selected and divided into control group (31 cases) and observation group (31 cases) according to different treatment schemes. The control group was treated with 3D-CRT, and the observation group was treated with DN regimen combined with 3D-CRT. The clinical efficacy, swallowing function grading method score (Stooler score), European Organization for Research and Treatment of Cancer Quality of Life Scale score (EORTCQLQ-C30 score), esophageal cancer patients supplement scale score (QLQ-OESl8 score) and side effects were compared between the two groups.
Results The total effective rate of the observation group was 70.97% higher than that of the control group 41.94% (P<0.05); After treatment, Stooler score and QLQ-OESl8 score in the observation group were lower than those in the control group, and EORTC QLQ-C30 score was higher than that in the control group (P<0.05); There was no significant difference in the incidence of side effects between the two groups (P>0.05).
Conclusion   DN regimen combined with 3D-CRT is effective in the treatment of patients with advanced EC, which can effectively reduce the level of body tumor markers, improve the swallowing function and quality of life of patients, and further alleviate their clinical symptoms.