Effect of nifedipine combined with enalapril on senile coronary heart disease complicated with hypertension
硝苯地平联合依那普利治疗老年冠心病合并高血压的效果

摘要

目的 探讨老年冠心病合并高血压选择硝苯地平与依那普利联合治疗的效果。方法 本研究于我院以对照试验形式展开，选择年限为2020年10月-2021年10月期间心血管内科收治的冠心病合并高血压老年患者94例为对象，经随机交替法分为对照组（n=47）和观察组（n=47），对照组选择硝苯地平单一治疗、观察组选择硝苯地平与依那普利联合治疗，评价两组的临床治疗效果。结果 两组与治疗前相比，其血压水平与心功能指标降低，血清Lp-PLA2、HCY指标降低，且观察组均低于对照组（P＜0.05）；两组不良反应发生率相比，观察组低于对照组（P＜0.05）。结论 对冠心病合并高血压的老年患者选择硝苯地平与依那普利联合治疗的疗效更好，对其血压、心功能、血清指标的改善作用明显，且不良反应较少、治疗安全性更高，应加强临床中应用力度。

Abstract

Objective To investigate the effect of nifedipine combined with enalapril in the treatment of elderly patients with coronary heart disease complicated with hypertension.
Methods This study was carried out in the form of controlled trial in our hospital. A total of 94 elderly patients with coronary heart disease complicated with hypertension admitted to the Department of Cardiovascular Medicine from October 2020 to October 2021 were selected as the subjects and divided into control group (n=47) and observation group (n=47) by random altercountry method. The control group was treated with nifedipine alone, while the observation group was treated with nifedipine combined with enalapril. The clinical treatment effect of the two groups was evaluated.
Results Compared with before treatment, the blood pressure level and cardiac function indexes, serum LP-PLA2 and HCY indexes of the two groups were decreased, and the observation group were lower than those of the control group (P < 0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (P < 0.05).
Conclusion   The combination of nifedipine and enalapril in the treatment of elderly patients with coronary heart disease complicated with hypertension has better efficacy, and has obvious improvement effect on blood pressure, cardiac function and serum indexes, and has less adverse reactions and higher treatment safety. It should be strengthened in clinical application.