Analysis of the therapeutic effect of glimepiride combined with metformin on elderly diabetes
格列美脲联合二甲双胍对老年糖尿病的治疗作用分析

摘要

目的 探究老年糖尿病使用格列美脲+二甲双胍的治疗效果。方法 文章研究人员选取时间2021年1月到2022年4月，共选取研究患者60人，均为院内老年糖尿病患者，随机分成联合组（联合药物疗法）、对照组（单一用药），每组30人，比对两组疗效。结果 联合组用药后患者血糖和血脂指标更趋近于正常值，P值＜0.05；联合组两项生活质量评分均高于对照组，P值＜0.05；联合组患者aPTT、PT和TT指标高于对照组、Fbg低于对照组，组间数据对比P值＜0.05；联合组病人治疗后胰岛功能显著优于对照组，P值＜0.05。结论 老年糖尿病单用二甲双胍疗效有限，联合用药对患者血糖、血脂和血管内皮功能具有明显改善功效。

Abstract

Objective To explore the therapeutic effect of glimepiride + metformin on elderly diabetes.
Methods the researchers selected 60 patients from January 2021 to April 2022, all of whom were elderly diabetes patients in hospital. They were randomly divided into combined group (combined drug therapy) and control group (single drug), with 30 people in each group. The curative effects of the two groups were compared.
Results the indexes of blood glucose and blood lipid in the combined group were closer to the normal value (P<0.05); The scores of both quality of life in the combined group were higher than those in the control group (P<0.05); The PTT, Pt and TT indexes in the combined group were higher than those in the control group, and the FBG was lower than that in the control group. The data comparison between the groups was p<0.05; The islet function of the combined group was significantly better than that of the control group after treatment, P<0.05.
Conclusion   the efficacy of metformin alone is limited in elderly diabetes. The combined use of metformin can significantly improve blood glucose, blood lipids and vascular endothelial function in patients with diabetes.