Efficacy analysis of injection of mouse nerve growth factor in the treatment of chronic polyneuropathy
注射鼠神经生长因子治疗慢性多发性周围神经病的疗效分析

摘要

目的 探讨慢性多发性周围神经病（CPP）患者注射鼠神经生长因子（mNGF）的疗效。方法共计纳入对象60例，均为CPP患者，双色球法分为两组，对照组用基础治疗，观察组则加mNGF注射治疗，对比疗效。结果 治疗前两组MTT评分、SDR评分、VAS评分、生活质量评分比较无明显差异（P>0.05），治疗结束，观察组MTT评分、生活质量评分更高，而SDR评分、VAS评分更低，差异显著（P<0.05）；两组不良反应无明显差异（P>0.05）。结论 CPP予以mNGF注射治疗，可更好地改善患者的运动功能与感觉障碍，减轻患者的疼痛程度，促进患者生活质量提高，但不会明显增加不良反应，值得应用。

Abstract

Objective To investigate the efficacy of mouse nerve growth factor (mNGF) injection in patients with chronic polyneuropathy (CPP).
Methods A total of 60 subjects, all of whom were CPP patients, were divided into two groups by the two-color ball method. The control group was treated with basic treatment, and the obser- vation group was treated with mNGF injection to compare the curative effects.
Results There was no significant difference in MTT score, SDR score, VAS score and quality of life score between the two groups before treatment (P>0.05). After treatment, the MTT score and quality of life score of the observation group were higher, while the SDR score and VAS score were lower. The difference was significant (P<0.05); there was no significant difference in adverse reactions between the two groups (P>0.05).
Conclusion   CPP with mNGF injection therapy can better improve the motor function and sensory disturbance of patients, reduce the pain degree of patients, and improve the quality of life of patients, but it will not significantly increase the adverse reactions, and it is worthy of application.