To investigate the efficacy of clopidogrel and aspirin combination therapy in acute cerebral infarction
探讨氯吡格雷联合拜阿司匹林治疗急性脑梗死的疗效

摘要

目的 实验将针对急性脑梗死患者实施氯吡格雷联合拜阿司匹林治疗，针对应用后的实际效果做出统计分析。方法 针对64例急性脑梗死患者进行治疗，样本选自2021年6月至2022年5月就诊的患者，并按照先后顺序分为2组，对照组为单一拜阿司匹林治疗，观察组为氯吡格雷联合拜阿司匹林治疗，对比治疗成果。结果 从数据可见，观察组患者的病情控制效果较好，在炎症因子（肿瘤坏死因子、高敏C反应蛋白以及白细胞介素-33）指标上低于对照组，具有统计学意义（P＜0.05）。同时，在凝血功能指标APTT和PT对比中，观察组保持了优势，数据高于对照，差异显著（P＜0.05）。最后，在生活质量测定QOL量表结果中，观察组患者的指标结果高于对照组，差异显著（P＜0.05）。结论 采用氯吡格雷联合拜阿司匹林对于急性脑梗死患者的康复治疗效果显著，快速地缓解了临床症状，改善炎症反应和患者的凝血功能指标，值得在继承借鉴中发展。

Abstract

Objective Clopidogrel and aspirin combined therapy were performed in patients with acute cerebral infarction, and to analyze the actual effect after application.
Methods 64 patients with acute cerebral infarction were treated from June 2021 to May 2022 patients, and were divided into two groups. The control group was single aspirin, and clopidogrel and aspirin in the observation group.
Results According to the data, the observation group had better disease control effect, with lower inflammatory factors (tumor necrosis factor, high-sensitive C-33) than the control group, which was statistically significant (P <0.05). Meanwhile, in the coagulation function index APTT and PT comparison, the observation group maintained the advantage, and the data was higher than the control, with a significant difference (P <0.05). Finally, in the quality of life measurement QOL scale results, the patients in the observation group also had higher index results than the control group, with significant differences (P <0.05).
Conclusion   Clopidogrel and combined aspirin were effective for patients with acute cerebral infarction, which quickly alleviated the clinical symptoms and improved the inflammatory response and blood coagulation function index.