International Journal of Internal Medicine. 2020; 1: (1) 7; DOI:10.12208/j.ijim.20200006.
Objective: To investigate the clinical efficacy of L-thyroxine treatment of subclinical hypothyroidism during pregnancy. Methods: 96 patients with subclinical hypothyroidism during pregnancy were divided into two groups according to the different treatment methods(n=48). The control group received no drug intervention, and the observation group used L-thyroxine tablets. Then compared the thyroid function, blood lipid changes and pregnancy outcome of two groups before and after treatment. Results: The levels of TSH, TC, TG and LDL-C in the observation group after treatment were significantly lower than control group (P<0.05). FT3, FT4, HDL-C levels before and after treatment in both groups had no significant changes (P>0.05). The total incidence of pregnancy complications in the observation group was significantly lower than control group (P<0.05). The rate of natural childbirth in the observation group was significantly higher than that in the control group. The incidence of cesarean section, preeclampsia and spontaneous abortion were significantly lower than those in the control group (P<0.05). The neonatal psychomotor development, mental development scores in the observation group were significantly higher than control group (P<0.05). Conclusion : L-thyroxin treatment of subclinical hypothyroidism in pregnancy can effectively increase serum folic acid levels, improve thyroid function, reduce the incidence of pregnancy complications and improve pregnancy outcomes.